New insights into CPPS

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webslave
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New insights into CPPS

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Nat Rev Urol. 2018 Dec 18

Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.
Clemens JQ1, Mullins C2, Ackerman AL3, Bavendam T2, van Bokhoven A4, Ellingson BM5, Harte SE6, Kutch JJ5,7, Lai HH8, Martucci KT9, Moldwin R10, Naliboff BD11, Pontari MA12, Sutcliffe S13, Landis JR14; MAPP Research Network Study Group.


Urologic chronic pelvic pain syndrome (UCPPS), which encompasses interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, is characterized by chronic pain in the pelvic region or genitalia that is often accompanied by urinary frequency and urgency. Despite considerable research, no definite aetiological risk factors or effective treatments have been identified. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network uses a novel integrated strategy to characterize UCPPS as a systemic disorder that potentially involves multiple aetiologies. The first phase, MAPP I, included >1,000 participants who completed an intensive baseline assessment followed by a 12-month observational follow-up period. MAPP I studies showed that UCPPS pain and urinary symptoms co-vary, with only moderate correlation, and should be evaluated separately and that symptom flares are common and can differ considerably in intensity, duration and influence on quality of life. Longitudinal clinical changes in UCPPS correlated with structural and functional brain changes, and many patients experienced global multisensory hypersensitivity. Additionally, UCPPS symptom profiles were distinguishable by biological correlates, such as immune factors. These findings indicate that patients with UCPPS have objective phenotypic abnormalities and distinct biological characteristics, providing a new foundation for the study and clinical management of UCPPS.


PMID: 30560936
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WS1234
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Re: New insights into CPPS

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Webslave...can you explain this in layman's terms?
Age: 32 | Onset Age: 29 | Symptoms: Urethral Pain/Irritation | Helped By: | Worsened By: | Other comments:
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Re: New insights into CPPS

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It says that patients, over a long period of time, have changes that can be seen in the structure and function of the brain. Many patients experience increased sensitivity to touch and other senses. Changes in patients can be seen in blood tests that look at the immune system. So in conclusion, UCPPS patients have distinct phenotype (physical, i.e. macro) and immune (i.e. micro) markers, which sets the direction for further research.
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