New biochemical markers for CPPS (Nature)

[webslave]

Multi-factors including Inflammatory/Immune, Hormones, Tumor-related Proteins and Nutrition associated with Chronic Prostatitis NIH IIIa+b and IV based on FAMHES project

CP is a complex male urologic disease. In order to investigate the potentially associated risk factors, and evaluate their predictive value, 22 different biochemical markers were investigated, covering inflammatory/immune markers, hormone markers, tumor-related proteins, and nutrition markers. Our results indicated that inflammatory/immune factors (IgE, C3, C4, CRP, ASO, and RF), hormone elements (Osteoc, TESTO, FSH, and insulin), tumor-related proteins (CEA and PSA), and a nutrition marker (FERR) were significantly associated with CP/CPPS or one of its sub-types. Among them, osteocalcin was consistently found to be a protective factor for CP/CPPS, NIH-IIIb, and NIH-IV prostatitis. Additionally, ferritin was more valuable in predicting NIH-IIIa prostatitis, independently. Further molecular and epidemiological studies with larger sample size are needed.

[dshoskes]

Sorry, this study is very weak. All diagnoses were made by questionairre. The CPSI was NEVER designed to diagnose CPPS. If a patient had a painful inguinal hernia he would score as CPPS. Artificial segmentation of WBC in EPS (and done without staining which often yields false positives). Final patient numbers too small to be powered to test so many variables. No time of day stated for blood draw (testosterone has to be an early morning draw to be accurate, especially in younger men). I could go on.

[webslave]

One would have thought that Nature would be more discriminating about what they publish. Sad, to quote the orange clown.

However the findings about ferritin are interesting. Back in the 1990s, when I was symptomatic, I found on three separate occasions that iron supplementation caused an exacerbation of symptoms.