For years, decades, I was looking outside for the answer, when I should have been looking inside all along. Looking at my genes. Because it turns out I have a genetic mutation on one of my genes, one with the rather apt acronym MTHFR. The result is that my body has trouble processing B-group vitamins.
But here’s the thing: I am far from being alone. The genetic mutation also affects close to one in five people and could be responsible for everything from mood disorder or multiple miscarriages to strokes, cardiovascular disease, diabetes and many other illnesses.
And the good news is that the potential treatment — folinic acid — is cheap, relatively easy to find and side-effect free.
The distinction between folinic acid* and the common dietary vitamin, B9 or folic acid, is an important one. Variations in the MTHFR gene mean I am unable to convert folic acid into a form my body can use — folinic acid — easily. That, in turn, can lead to a Pandora’s Box of health problems.
Folinic acid — cure for anxiety?
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Folinic acid — cure for anxiety?
How a vitamin cured my anxiety: Elisa Black’s story of lifelong struggle and new hope for the future
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Re: Folinic acid — cure for anxiety?
Webslave,
I was doing a search on Folic Acid and I'm surprised no one had commented on this article. Especially considering how many of us that suffer from CPPS symptoms also suffer from high anxiety and/or depression and that has caused A LOT of pelvic tension over the years. I want to avoid taking any SSRIs (I've taken Lexapro when I lost my job for 4 years, as recently as 2 yrs ago) and recently took a genetic test ordered by my psychiatrist. It came back that I have this exact homozygous mutation for MTHFR. Not processing Folic Acid and significantly increased Homocysteine levels (high risk heart disease). This all seems to have come to light in like the past couple years. My father died of heart disease at a young age
...I outlived him
. This says a lot since I have anxiety (stress levels) and knew I was genetically predisposed to heart disease. I also read that low Folic Acid levels can also lead to inflammation and chronic pain (no shit!?
). This all kind of makes sense now.
So I'm searching the web and this site for the correct OTC dosage to take without adverse side effects. I'm off the 5-HTP and I think I need to take L-Methylfolate and vitamin B12. The pharmacist pointed me to Glucosamine Chondroitin+D3 and 800mcg of Folic Acid. I think that's wrong considering I have the mutation. If you or anyone on the forum has posted any articles or taken anything OTC successfully, I'd appreciate it. The psychiatrist wrote out a prescription for Xaquil XR but it's like $60/month and not generic. I think there's also Deplin available. Supposedly these deliver the methylfolate better since those with the mutation can't break down the folic acid.
I found this article useful as well for anyone else interested in taking a more homeopathic route to working on their anxiety and want to read up more on the genetic mutation: https://www.dietvsdisease.org/l-methylfolate-5-mthf/
I was doing a search on Folic Acid and I'm surprised no one had commented on this article. Especially considering how many of us that suffer from CPPS symptoms also suffer from high anxiety and/or depression and that has caused A LOT of pelvic tension over the years. I want to avoid taking any SSRIs (I've taken Lexapro when I lost my job for 4 years, as recently as 2 yrs ago) and recently took a genetic test ordered by my psychiatrist. It came back that I have this exact homozygous mutation for MTHFR. Not processing Folic Acid and significantly increased Homocysteine levels (high risk heart disease). This all seems to have come to light in like the past couple years. My father died of heart disease at a young age




So I'm searching the web and this site for the correct OTC dosage to take without adverse side effects. I'm off the 5-HTP and I think I need to take L-Methylfolate and vitamin B12. The pharmacist pointed me to Glucosamine Chondroitin+D3 and 800mcg of Folic Acid. I think that's wrong considering I have the mutation. If you or anyone on the forum has posted any articles or taken anything OTC successfully, I'd appreciate it. The psychiatrist wrote out a prescription for Xaquil XR but it's like $60/month and not generic. I think there's also Deplin available. Supposedly these deliver the methylfolate better since those with the mutation can't break down the folic acid.
I found this article useful as well for anyone else interested in taking a more homeopathic route to working on their anxiety and want to read up more on the genetic mutation: https://www.dietvsdisease.org/l-methylfolate-5-mthf/
Age: 43 | Onset Age: 43 | Symptoms: burning in tip of penis/urethra has mostly faded; mild pain in right testicle; main pain comes from anterior levator ani spasm | Helped By: hot baths, healing time days after PT, klonopin .25-.5mg, meditation (trying to learn) |Taking: 100mg zoloft (recent onset of tinnitus), Omega-3s, VSL3 Probiotic, Q-Rol, Zyflamend, Chelated Magnesium 500Mg | Worsened By: anxiety, depression, thinking about it too much | Other comments: sitting and pireneal and most penis pain/burning is gone from PT but just developed pain after ejaculation coming from levator; some pain from sitting too long depends on spasm; listening to Jon Kabat Zinn helps; need to de-stress my life; my PT says I'm at rock bottom and it's a long journey so I try to tell myself to be realistic about how long it will take and that this takes time so I try not to let it affect my social life